Previous efforts to circumvent the problem of the size limitation imposed by the AAV vector have focused mainly on altering the candidate genes into ‘mini-expression cassettes’ suitable for ...

Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy.

To specifically select for viruses that successfully traversed the BBB, Deverman injected Cre transgenic mice with his capsid ... they loaded green fluorescent protein (GFP) into each virus, ...