In this manufacturing process, the baculoviruses play a dual role, functioning as the ‘helper’ virus normally required ... enabling far more efficient AAV production than adherent cell cultures.

Previous efforts to circumvent the problem of the size limitation imposed by the AAV vector have focused mainly on altering the candidate genes into ‘mini-expression cassettes’ suitable for ...

Nanoneedle technology offers the capability to simultaneously quantify titers of true, full viral genomes and a range of ...

ELEVECTA™ producer cell line is a stable line for inducible AAV production. It is a true producer cell line that has Rep, Helper, Cap, and gene of interest (GOI) stably integrated into the host cell’s ...

Safe and effective gene therapy strategies depend on robust and reliable adeno-associated virus (AAV) mediated therapeutic gene delivery ... Download this article from Polyplus, now part of Sartorius, ...

Yet, large-scale AAV production is still a bottleneck for commercialization. A new, streamlined AAV purification process that is both universal and scalable eases that constraint. After the AAV ...

In 2014, researchers combined DNA barcoding with next-generation sequencing (NGS) to develop the adeno-associated virus (AAV) barcode-seq technology for streamlining ...

Researchers have demonstrated, for the first time in the world using mice, the ability to overcome significant challenges in gene therapy using adeno-associated virus vectors (AAV), specifically ...

OXB (LSE: OXB), a quality and innovation-led cell and gene therapy CDMO, today announces the appointment of Jefferies International Limited ("Jefferies") as its Joint Corporate Broker and Joint ...

Older women could be vulnerable to harmful inflammation from new gene therapies to treat incurable eye diseases, new research has found. The ...