However, we found that most acute myeloid leukemia (AML) cells, especially M4 and M5 subtypes, produce TNF and show basal level activation of RIP1/RIP3/MLKL signaling, yet do not undergo necroptosis.

The French-American British classification of the AML samples consisted of six AML-M4, seven AMLM4eo, one AML-M3 and one AML-M1; myelodysplastic syndrome (MDS) samples were three RA, six RAEB-1 ...