The rapid advance in next generation sequencing technologies, such as single-cell RNA-sequencing (scRNA-seq), has revolutionized our understanding of AML pathogenesis by enabling high-resolution ...

These findings warrant further exploration into the mechanisms by which SDF-1α contributes to AML pathophysiology and treatment outcomes. Moreover, prospective clinical trials are needed to validate ...

Collectively, array studies have identified new clonal deletions and amplifications that probably contribute to disease pathogenesis ... and less progression to AML (p = 0.033) [11] Graubert ...

He was appointed by President Obama to the National Cancer Advisory Board in 2015. Ley studies the molecular pathogenesis of Acute Myeloid Leukemia (AML). He and his colleagues sequenced the first ...

How is acute myeloid leukemia (AML) treated? The main treatment for most types of AML is chemotherapy, sometimes along with a targeted therapy drug. This might be followed by a stem cell transplant.

TBI remained significantly associated with reduced adjusted risks of grade 3 to 4 aGVHD and moderate-severe cGVHD.

ALL = Acute lymphoblastic leukemia; AML = Acute myeloid leukemia; FTI = Farnesyltransferase inhibitor; HDAC = Histone deacetylase; NF = Nuclear factor; Ph = Philadelphia chromosome; TKI = Tyrosine ...