which are topographically distinct from the acetylcholine binding site, allows selective modulation of a particular muscarinic receptor subtype to be achieved. Using an assay that is based on ...

The crown jewel of the acquisition was seen as emraclidine, an allosteric modulator that selectively targets the muscarinic acetylcholine 4 receptor subtype. It was seen as a potential next ...

1 Nicotine-induced pain relief appears to work through the nicotinic acetylcholine receptors (nAChRs), heteropentameric ion channels activated ... have traced the sex differences to the α4 β2 subtypes ...