Pancreatic ductal adenocarcinoma (PDAC) has long been considered to arise from pancreatic ducts on the basis of its morphology, the occurrence of dysplasia in putative preneoplastic ductal lesions, ...
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Novel organoid mimics all three key cell types of pancreas to offer a view of early fetal developmentThis organoid contains the three main types of pancreas cells: acinar cells, ductal cells, and endocrine cells. Each of these cells plays a vital role. Acinar cells release enzymes that help break ...
It’s also possible for adenocarcinoma to develop from the cells that create pancreatic enzymes. When this occurs, it is called acinar cell carcinoma, which accounts for 1 percent to 2 percent of ...
Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling ...
Relationship of circulating tumor DNA (ctDNA) tumor fraction with prognosis in patients with metastatic pancreatobiliary cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...
1 Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA Most pancreatic cancers arise from a single cell type, although mixed pancreatic ... yielded diagnosis of invasive mixed ...
EVEREST-2: A seamless phase 1/2 study of A2B694, a logic-gated Tmod chimeric antigen receptor T-cell (CAR T) therapy, in patients with pancreatic cancer (PANC) or other mesothelin (MSLN)-expressing ...
NKX2.2 not detected in pancreatic progenitors before endocrine commitment Differentiation of the acinar lineage Nkx6.1 excluded from tip cells by e14.5 (CS19–20) (13) NKX6.1 still detected in ...
Research in the Pancreatitis and Acute Outcomes Laboratory has determined the role of the nonreceptor tyrosine kinase c-Src in the maturation and packaging of the enzyme amylase into zymogen granules ...
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