Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling ...

Relationship of circulating tumor DNA (ctDNA) tumor fraction with prognosis in patients with metastatic pancreatobiliary cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...

EVEREST-2: A seamless phase 1/2 study of A2B694, a logic-gated Tmod chimeric antigen receptor T-cell (CAR T) therapy, in patients with pancreatic cancer (PANC) or other mesothelin (MSLN)-expressing ...

Here, we review the recent literature on how single-cell transcriptomic approaches have changed our understanding of pancreas biology and disease progression. The exocrine pancreas has more epithelial ...

This organoid contains the three main types of pancreas cells: acinar cells, ductal cells, and endocrine cells. Each of these cells plays a vital role. Acinar cells release enzymes that help break ...

Acinar cystic transformation (ACT) of the pancreas is a rare non-neoplastic cystic lesion. It is difficult to distinguish from more concerning pathology, particularly a side-branch duct intraductal ...

NKX2.2 not detected in pancreatic progenitors before endocrine commitment Differentiation of the acinar lineage Nkx6.1 excluded from tip cells by e14.5 (CS19–20) (13) NKX6.1 still detected in ...

This cancer occurs in the lining of the ducts in the pancreas. It’s also possible for adenocarcinoma to develop from the cells that create pancreatic enzymes. When this occurs, it is called acinar ...