An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and ...
Hans Clevers 研究团队利用类器官技术解锁胰腺再生新篇章!刊发在《Cell》(IF:45.5)的最新研究论文[1]显示,科学家通过类器官和单细胞基因测序等技术,发现人类胎儿胰腺中的LGR5+干细胞群,并开发了一种能够在体外长期扩增并具备分化潜力的类器官系统,首次实现了人类胰腺三种主要细胞类型的体外生成。该研究为揭示胰腺疾病发育机制,开发治疗胰腺炎、糖尿病等胰腺相关疾病新药提供了新策略。
来自MSN2 个月
Novel organoid mimics all three key cell types of pancreas to offer a view of early fetal ...This organoid contains the three main types of pancreas cells: acinar cells, ductal cells, and endocrine cells. Each of these cells plays a vital role. Acinar cells release enzymes that help break ...
TLS are accumulations of lymphoid cells that share similar cellular ... The organoids expressed epithelial ductal and acinar markers and recapitulated the epithelial diversity.
Ductal carcinoma of the prostate might be the primary diagnosis or an incidental finding mixed with acinar adenocarcinoma during pathologic examination.
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