The molecular profile of activated microglia varies, depending on the type of neural injury to which they are responding 13. It is likely that the microglial response to different therapeutics is ...

Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing ...

When they read existing research on this topic, the team discovered that in early stages of the disease, microglia are not yet activated. At the early stages, they're mostly homeostatic ...

Researchers at University of Tsukuba have discovered a novel mechanism involved in brain development. They found that small fragments called micronuclei produced by neuronal nuclei are released into ...

Chronic neuroinflammation, primarily driven by activated microglia and astrocytes, is a hallmark of neurodegenerative ...

However, when exposed to nefarious stimuli, microglia transition from a resting elongated and ramified form to an activated amoeboid state, coupled with an overall enhanced pro-inflammatory phenotype.

Understanding how the infection activates microglia, the brain’s immune cells, through interactions with neurons. Assessing how activated microglia influence surrounding neurons in response to ...

Ashvattha Therapeutics (“Ashvattha”), a clinical-stage company advancing a new class of nanomedicine therapeutics that traverse tissue barriers to selectively target and reprogram activated cells in ...