Medically reviewed by Lindsay Cook, PharmDMedically reviewed by Lindsay Cook, PharmD Low alkaline phosphatase (ALP) can be a sign of several different conditions, including thyroid disease ...

Background Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism, caused by mutations in the ALPL (alkaline phosphatase liver type) gene, with reduction of activity of the ...

We present a case of a 50-year-old woman with low impact fractures and loss of teeth at a young age. She also had a low alkaline phosphatase and was diagnosed with adult hypophosphatasia. Although the ...

Elevated levels of serum total alkaline phosphatase (T-ALP) have been linked with decreased bone mineral density (BMD), ...

is a genetic disease caused by one or more mutations in the alkaline phosphatase (ALP) gene, which encodes tissue-specific ALP and affects the mineralization process. Accordingly, arthralgia, ...

1 Term infants at high risk of vitamin D deficiency have higher mean alkaline phosphatase (ALP) activity than controls, indicating increased bone turnover.1 Despite this, ALP activities remain within ...

1 Department of Paediatrics, Royal National Orthopaedic Hospital NHS Trust, Middlesex, UK 2 Department of Paediatric Endocrinology, Central Manchester NHS Foundation Trust, Manchester, UK Objective ...

We searched for studies from 1980-2011 using Medline and combining the search terms ‘alkaline phosphatase’ AND (preterm OR premature OR low birthweight infant). We identified studies with measures of ...

Term high-risk newborn infants have higher mean alkaline phosphatase (AP) concentrations than controls, indicating increased bone turnover, although values remain within the normal range. There is ...

Introduction Serum alkaline phosphatase levels in adults range between 20 and 120 U/L. When bone disease is excluded, an elevation suggests biliary obstruction, injury to the bile duct epithelium, or ...