Although prostate cancer cells are often initially sensitive to androgen ablation, they eventually lose this response and continue to survive, grow and spread in the absence of androgenic steroids.

近日，西湖大学吴连锋团队在 Cell Reports 杂志发表了一篇题为“Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice ...

Medically reviewed by Lauren Schlanger, MD Androgen insensitivity is an umbrella term for a number of genetic conditions where the body does not respond appropriately to testosterone and other ...

First, we must implement the use of androgen assays with sensitivity in the lower concentrations seen in women after iatrogenic menopause and as they age. Second, we must establish the normal ...

Furthermore, emerging evidence has also suggested the development of sex-specific methylation patterns, particularly in androgen-sensitive regions. However, the precise role of androgens in ...

Female androgens are derived from either the adrenal and peripheral conversion of the adrenal sex steroid precursor, dehydroepiandrosterone, or from direct ovarian production. Adrenal ...

That suggests the androgen-sensitive cells then communicate to neighbors through paracrine signaling, inducing changes across the whole tissue, say the researchers. The work characterizes the ...