Glutamate uptake is mainly accomplished by astrocytes which either convert glutamate to glutamine or feed it into their own metabolism. Normally, the astrocytic glutamate transporters are indirectly ...

Astrocytes from both groups had deficits in glutamate signaling. The cool part is what happened next: When they exposed astrocytes to clozapine, glutamate signaling normalized—but only in the ...

Studies have shown that lurasidone can suppress the release of L-glutamate from astrocytes, which are star-shaped glial cells in the brain that support neuronal function. This suppression is ...

Astrocytes connect and support communication ... NO synthesis is self-sustaining, supported by the NO-glutamate loop, but blocking molecular steps for NO-synthesis or those that trigger glutamate ...

Some examples of mouse models in which astrocyte protein function is altered are detailed in Table 1. In addition to cellular hypertrophy and upregulation of specific genes associated with ...

glutamate, or adenosine. Astrocytes regulate clock gene expression and neuronal synchrony in culture systems, but how astrocytes regulate neuronal function within the SCN remains largely unknown. SCN ...

Release of neurotransmitters such as glutamate from astrocytes can contribute to ischemic brain damage. Because astrocytes are coupled into networks by gap junctions, they are also important in ...

We transduced mouse cortical astrocytes cultured from four litters of embryonic ... Both mRNA and protein levels of glutamate transporter 1 (GLT-1) declined with passage number. Immunostaining at ...

Objectives Our objective is to realize a PET imaging tracer for the CNS L-glutamate (L-Glu) transporter EAAT2 (Excitatory Amino Acid Transporter 2) found on astrocytes. Transport by EAAT2 is the ...

Neuropathological studies have demonstrated an increased reactivity of astrocytes and oligodendroglial cells, which reflects a process of neuroinflammation and which critically regulate processes of ...

His current research interests include astrocyte–neuron interaction, computational neuroscience, tactile sensing, and neuromorphic engineering.