Then, depending on the stimuli that initiated the autophagy process, the cargo is either degraded or recycled. In 2004, fifty years after Novikoff and de Duve observed lysosomes under the electron ...

Then, depending on the stimuli that initiated the autophagy process, the cargo is either degraded or recycled. In 2004, fifty years after Novikoff and de Duve observed lysosomes under the electron ...

The autophagosomes, autolysosomes and lysosomes can be considered as different stages of the cellular recycling process. Therefore, when cells notice they have too much "junk" inside, autophagy ...

The autophagosomes, autolysosomes and lysosomes can be considered as different stages of the cellular recycling process. Therefore, when cells notice they have too much "junk" inside, autophagy ...

In wild-type mice, host cells respond by releasing exosomes studded with the protein ADAM10, which act as decoys, but mice deficient in an autophagy protein called ATG16L1 release far fewer of the ...

“Decoy exosomes provide protection against bacterial toxins,” Nature ... had found in previous work that a key protein involved in autophagy also makes mice less susceptible to MRSA and alpha-toxin.

The calcium efflux results in higher local calcium concentration than the rest of the cell, promoting the fusion of the lysosome with endosomes. In summary, the authors wrote, “We present a model in ...

To combat this autophagy, the research team designed a photoreactive compound that integrates morpholine and iridium. Morpholine selectively targets cell lysosomes, the organelles where autophagy ...

This inhibition boosts autophagy in keratinocytes—key players in wound repair—by promoting cell health, proliferation, and migration. Demonstrating that exosomes enriched with miR-4645-5p from ...

Nutrient deprivation inhibits mTORC1 and activates AMPK, which then dephosphorylates or phosphorylates ULK1 at different sites, leading to the activation of the ULK complex and initiation of the ...