The rationale for the use of anti-BAFF therapy in human SLE is evident from several preclinical studies... Belimumab, a humanized antibody against B-cell-activating factor (BAFF, also known as ...

Signaling through BAFF-R and BCMA increases the levels of the ... clinical trials and appear well tolerated. Their efficacy in SLE is unknown at present. [58–59] ...