whose elegant drawings show cell shrinkage, nuclear fragmentation and apoptotic body formation, all of which are now accepted hallmarks of apoptosis (Box 1). While members of the Bcl-2 family were ...

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles ... (in particular BCL2 and BCL-XL) through a BH3 domain.

After treating a tumour with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do not divide, are involved in the ageing process and are resistant to cell ...

After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do not divide, are involved in the aging process, and are resistant to cell ...

ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein ... against P53-negative and FLT3-ITD-positive cell lines. Enhanced activation of apoptosis was observed in leukemia patient ...

In addition to conservation of the cellular pyrimidine pool, low-glucose levels also prevented the activation of the proteins Bcl-2-associated X protein (Bax ... consumption and exhaustion of uridine ...