Although only the second approach yielded a high-resolution structure (2.3 Å ... active receptor mutants and biased receptor mutants that signal via one or the other signaling pathway may ...

which works as an on/off switch for the beta-2 adrenergic receptors. To activate the fight-or-flight pathway, hormones like adrenaline bind directly into tailor-made slots in beta 2-andrenergic ...

Adrenergic receptors present in the mammalian cardiac muscle are now thought to belong to the beta type, and to initiate stimulation when occupied. Isoprenaline 2 is the catecholamine which best ...

[6] β-blockers differ from one another, however, with regard to many pharmacologic properties, including β1/β2-adrenergic receptor selectivity and vasodilatory capabilities. David Wojciechowski ...

Such patients may be less responsive to positive inotropic agents, whereas the beneficial effects of nesiritide, which are not dependent on the β-adrenergic receptor signal-transduction pathway ...