Beta-lactamase inhibitors are designed to overcome a key resistance mechanism that allows pathogens to protect themselves from beta-lactams, one of the most commonly-used antibiotic classes.
efflux pumps to expel antibiotics and beta-lactamase enzymes to inactivate beta-lactam antibiotics. New antibiotics must overcome resistance mechanisms using more efficient penetration through the ...
He has been the chair of the Department of Pharmacology and Chemical Biology since 2007. His main research interest is understanding the molecular basis of beta-lactamase-mediated antibiotic ...
Ten months after Pfizer scored approval in Europe for Emblaveo (aztreonam and avibactam) to treat complicated intra-abdominal infections (cIAIs), AbbVie has done the same in the U.S., ...
Together, they’re being studied as a potential treatment option for serious bacterial infections caused by antibiotic-resistant gram-negative bacteria, including Extended Spectrum Beta-lactamase ...
Augmentin is a prescription therapy that uses this method, combining the antibiotic amoxicillin with the inhibitor, clavulanic acid. Metallo-beta-lactamase is a bacterial protein at the root of ...