system — the final biochemical pathway in the production of ATP — result in devastating, mainly multisystem diseases. The OXPHOS system is under dual genetic control, which involves an ...

This commentary highlights the potential of an alternate regressive method for biochemical pathway design and generation, inspired by the retro-evolution hypothesis and the concept of retrosynthesis.

A new biochemical pathway linked to diet and body weight ... have remained mysterious. "Despite this genetic association, no one really knew what PTER did or why it was linked to body mass index ...

We pursue biochemical approaches to reconstitute key intermediates or complexes in these pathways and combine them with single particle cryo-EM and x-ray crystallography in conjunction with genetics ...

Moritz Lehners, Hannes Schmidt, Maria T K Zaldivia, Daniel Stehle, Michael Krämer, Andreas Peter, Julia Adler, Robert Lukowski, Susanne Feil, Robert Feil: Single-cell analysis identifies the ...

Real-time observation of certain biochemical processes in blood vessels from mice has revealed a previously unknown ...

This analysis uncovers the genetic and biochemical underpinnings of metabolomic diversity, with a focus on the phenylpropanoid pathway, a central hub for flavonoid and other bioactive compound ...

Prior clinical studies have identified adverse events, and remdesivir has been shown to inhibit mitochondrial RNA polymerase in biochemical experiments, yet little is known about the specific genetic ...