HIV-1 entry into cells is an attractive target for new antiviral agents. But will inhibitors aimed at the CCR5 co-receptor force HIV-1 to evolve more virulent forms? Other targets for entry ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of glycoproteins gp41 and gp120 must bind with the CD4 receptor on the membrane of ...

She received a cord blood transplant to treat the AML, receiving stem cells carrying a genetic mutation (CCRΔ5/Δ32) which means they lack the CCR5 co-receptor used by HIV to get access to cells ...

On left, the HIV virus binds to CD4 T cell CD4 receptor, which will allow the ... [+] co-receptor CCR5 to melt and release the viral RNA into the cytoplasm. After reverse transcription ...

CCR5 has been correlated with impairments in memory consolidation in aged mice, which was reversed with a CCR5 knockout drug that inhibits this receptor ... will be able to co-transport our ...