The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Sequence of the gene CCR5 Delta 32 in acrylic paint on polyester taffeta. The CCR5 gene produces the CCR5 receptor protein which normally inserts into the cell membrane. The human immunodeficiency ...

Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis. Results Mice lacking CCL2 or CCR2, but not CCL5 or CCR5, were protected against OA ...

Given the negative prognosis associated with high CCL5 serum levels in human patients and its diverse functions in chemokine and paracrine signaling (Aldinucci et al., 2020), we hypothesized that ...

My early research focused on the signaling functions in T cells of the CD4 and CD8 coreceptor molecules ... We also identified CD4 and the chemokine receptor CCR5 as the receptor complex used by HIV ...