调节性T细胞是维持机体免疫稳态的CD4+ T细胞亚群，也是肿瘤微环境中免疫抑制屏障的主要构成细胞。因此，特异性地调控肿瘤微环境的Treg细胞使其功能与稳定性发生改变，将能够促进肿瘤杀伤反应的发生。

Mozart Therapeutics, the leading developer of CD8 Treg network modulators in autoimmune disease, announces the presentation ...

When the immune system recognizes an external pathogen two key T cells arrive at the scene – CD4+ T cells known as helper cells and CD8+ T cells known as killer cells. The first group of Treg cells ...

One cluster displayed a Treg phenotype ... of CD8 T cells in TDLNs and triggered a powerful anti-tumor response. "In around 10% of patients where the stem-like CD4 cell is active, there is ...

Selectively binds and activates CD8 Treg; does not activate cells that express only one target, including other ICOS-expressing immune cells Extends survival and decreases disease score in a ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

A significant (p = 0.05) increase in the ratio of T helper to suppressor cells (CD4:CD8) was found, along with a significant (p = 0.015) increase in CD4CD25 regulatory T cells. Production of the ...

Comparatively, GZMB-expressing KIR+ CD8+ T-cells have been found to suppress autoimmunity by eliminating autoreactive CD4+ T-cells. The current study is the first to report the persistence and re ...