*仅供医学专业人士阅读参考在奇点糕的印象里，“有亲和力”这四个字一般很难和什么负面的事情或者评价相关，毕竟与人亲近、让人容易接纳之类的特质，听着都是好事儿啊？就算在医学领域，药物与作用靶点的亲和力（Affinity）虽然不是越高越好，但高一点也比低一点好吧？但就是说，凡事总有例外。今天，美国康涅狄格大学医学 ...

b.使用药物阻断PD-1和其配体的结合通路，CD28介导的共刺激信号作用于T淋巴细胞，诱导T淋巴细胞增殖爆发，药物产生疗效，使肿瘤和被病毒感染的靶细胞得到控制（图3b）。

The anti-correlation of PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells suggests the potential for combination therapy ...

根据 2024 年 12 ...

【导读】富含丝氨酸精氨酸的剪接因子1（SRSF1）是多种癌症中的一种关键致癌剪接因子，通过翻译后调控促进异常基因表达。虽然SRSF1的原癌基因功能已得到证实，但抑制肿瘤内在SRSF1对肿瘤微环境的影响及其对CD8 T细胞介导的抗肿瘤免疫的影响仍不清楚 ...

PD-1是CD28家族的一员，在多种免疫细胞中表达，特别是外周组织中活化的CD8+T细胞、CD4+T细胞和B细胞中[2]。PD-1有两个结合配体，PD-L1(B7-H1或CD274 ...

A new research paper was published in Oncotarget's Volume 16 on January 20, 2025, titled "Anti-correlation of KLRG1 and PD-1 ...

and CD8-positive suppressor T cells, which restrain certain types of immune response. Interferon-α (IFN-α) is linked to type 1 diabetes (T1D), but how IFN-α impacts auto-antigen presentation is ...

In addition, researchers found that targeting BFAR could not only revive the antitumor activity of aged CD8 + T cells, but also enhance the sensibility of PD-1 blockade-based immunotherapy.

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...