The anti-correlation of PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells suggests the potential for combination therapy ...
In mice infected with lymphocytic choriomeningitis virus (LCMV), Ahmed found PD-1 upregulated in functionally-impaired CD8 T cells. The team then showed that preventing PD-1 activation by blocking its ...
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Study finds anti-correlation of KLRG1 and PD-1 expression in tumor fighting T cellsA new research paper was published in Oncotarget's Volume 16 on January 20, 2025, titled "Anti-correlation of KLRG1 and PD-1 expression in human tumor CD8 T cells." ...
In addition, researchers found that targeting BFAR could not only revive the antitumor activity of aged CD8 + T cells, but also enhance the sensibility of PD-1 blockade-based immunotherapy.
PD-1是CD28家族的一员，在多种免疫细胞中表达，特别是外周组织中活化的CD8+T细胞、CD4+T细胞和B细胞中[2]。PD-1有两个结合配体，PD-L1(B7-H1或CD274 ...
White button mushrooms promoted antitumor activity among men with prostate cancer, according to results of an ongoing ...
b.使用药物阻断PD-1和其配体的结合通路，CD28介导的共刺激信号作用于T淋巴细胞，诱导T淋巴细胞增殖爆发，药物产生疗效，使肿瘤和被病毒感染的靶细胞得到控制（图3b）。
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Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammationResearchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent ...
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