This effect is associated with increased infiltration and activation of cytotoxic T lymphocytes and prolonged survival. These new insights into the role of CXCR4 in dendritic cells may help ...

Xolremdi, a selective CXC chemokine receptor 4 (CXCR4) antagonist, is the first therapy specifically indicated in patients with WHIM syndrome, a rare, combined primary immunodeficiency and chronic ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Surface-bound MIF induced arrest of primary human monocytes through CXCR2 and triggered the arrest of primary human effector T cells via CXCR4. Furthermore, CD74 (a MIF-binding protein ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...