The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

Keywords: cAMP, cGMP, PKA, PKG, Phosphodiesterase inhibitors, endocrine disorders, cell signaling, mouse models, metabolic disorders, cardiovascular diseases Important note: All contributions to this ...