CDKN1B 5′UTR mediates its cell cycle-dependent translation and several ... reduces p27–CDK2 inhibition and transforms p27 from inhibitor to substrate of cyclin–CDK2 complexes.

The universal cell-cycle inhibitor p21 Cip1/WAF1 is phosphorylated ... as a mechanism of deregulating cell proliferation in cancer. Figure 1: Oncogene Her2/neu-initiated, Akt-mediated p21 Cip1 ...

Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been ...

Trilaciclib significantly reduced chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer, which ...

In breast cancer, these proteins can become overactive and cause the cells to grow and divide uncontrollably. CDK4/6 inhibitors interrupt these proteins to slow or even stop the cancer cells from ...

CDK4/6 inhibitors like abemaciclib and ribociclib improve invasive disease-free survival in breast cancer trials, but controversy surrounds study designs, bias, and cost-effectiveness, raising ...

The company is developing a CDK2 inhibitor called INX ... with a key role in controlling the cell cycle. They have become an attractive target for new cancer therapies. Patrick Roberts, CEO ...

The membrane-associated tyrosine/threonine protein kinase 1 (PKMYT1) regulates cell cycle progression and maintains genomic integrity. If it is dysregulated, cells may enter mitosis prematurely, ...

The model, which is predominantly based on genetic gain- or loss-of-function studies, implies that RAS is locked into an active state in cancer and ... phases of the cell cycle, DNA replication ...

My laboratory has combined biochemical, molecular, cellular, and genetic approaches to investigate the roles of CDK inhibitors in differentiation ... the genes and and molecular mechanisms by which ...

Whereas dendritic cells are critical for kickstarting the cancer immunity cycle in the lymph node ... one promising strategy will be to use COX inhibitors, such as aspirin—drugs that block ...

Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...