脂肪肝疾病发展至肝细胞癌（HCC）的机制一直是现代医学研究中的重要课题。在2025年1月1日发表在Nature期刊上的一篇题为“FBP1 controls liver cancer evolution from senescent MASH hepatocytes”的研究中，来自华西医院和美国加州大学圣地亚哥分校的联合科研团队揭示了一个关键的酶——果糖-1,6-二磷酸酶1（FBP1）在这个过程中所 ...

Molecular oncology is revolutionizing cancer care by using genetic profiling to tailor personalized treatments, improving ...

Evolutionary biology isn’t a sub-topic of cancer sciences - it is a conceptual framework for everything in cancer. In recognition of this important development and the research opportunities it ...

we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.

The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically ...

Discover how exercise enhances cancer treatment effectiveness, boosts immunity, and improves patient outcomes with ...

However, it rarely occurs in other cancer types, thus highlighting the need for large-scale analysis of rare cancers to identify the distinct mutations that underpin their evolution.

By identifying the genetic trajectory of tumor evolution, clinicians can potentially devise strategies to intercept the road ...

represents a significant step toward understanding resistance evolution. The hope is that it may lead to innovative ...

Scientists have found that a test to detect circulating tumor DNA can predict lung cancer outcome. Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to ...

Documented palliative goals of care rarely occurred among adolescents and younger adults with cancer before the last 30 days of life.