Many genes involved in cell motility and remodeling of ... both of which cause DNA damage and consequent cell-cycle arrest at multiple checkpoints. DNA-damage experiments were performed in ...

Other proteins act to hold the cell at distinct points in the cycle (checkpoints) and are known as tumor suppressor genes. Apart from those with a clearly regulatory role, many proteins have ...

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. Natural killer (NK) cells are pivotal in the innate immune response ...

Checkpoint activation results in the stabilization of stalled forks, prevents further origin firing, and creates a cellular milieu that promotes the resolution of replication fork blocks before entry ...