The subsequent breakdown of the nuclear envelope terminates prophase and initiates prometaphase ... characterized by the activity of defined cell-cycle regulators, in particular the mitotic ...

During the S (DNA-replication) phase of the cell cycle, each centriole cylinder duplicates ... at the onset of mitosis (M phase), in early prophase, thus forming two centrosomes; the two resulting ...

Mitosis orchestrates eukaryotic cell division, maintaining genetic fidelity and playing a key role in development, tissue homeostasis, and cancer progression.

Interphase The cell spends most of its life in this phase. The DNA in chromosomes copies itself ready for mitosis. Prophase The DNA in chromosomes and their copies condenses to become more visible.

Meiosis is characterized by a series of well-defined transitions: During the prophase of meiosis I, homologous chromosomes undergo pairing ... We are further investigating the surveillance mechanisms ...