在脂肪组织中，BMAL1 功能缺失与肥胖之间存在关联。肥胖人类和小鼠的脂肪组织中，Arntl 及其靶基因的表达水平显著降低，且 ARNTL 甲基化与人体测量参数相关，其多态性与中心性肥胖及性别特异性的肥胖遗传易感性有关。此前利用小鼠模型的研究提示，脂肪组织中脂解失调可能是导致肥胖的一个因素，但 Arntl 功能障碍引发肥胖的具体机制尚未完全明确。

Sustained exposure to pathological stress stimulates the heart to hypertrophy, increasing disease and mortality risk. New therapies to blunt this process include targeting enzymes below the cell ...

However, under pathological conditions such as hypertension, these cells can undergo hypertrophy and hyperproliferation, leading to vascular remodeling. Recent research has focused on the ...

The following is a summary of “Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for ...

If you're on a quest for hypertrophy, or maximum muscle growth, it's not just about lifting weights. Science shows that one ...