Receptors are generally transmembrane proteins, which bind to signaling molecules outside the cell and subsequently transmit the signal through a sequence of molecular switches to internal ...

These distinct outputs facilitate signal discrimination by target gene networks and control cell phenotypic responses. The transfer of information through signalling networks is regulated at ...

Varjosalo Lab's longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate ...

Moreover, increased type I interferon signaling has been identified ... is associated with impaired Treg cell function and ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...