Immune checkpoint molecules play a crucial role regulating immune responses, maintaining a balance between fighting diseases and preventing excessive inflammation. These molecules either enhance or ...

Small molecule chemical compounds block the function of major immune checkpoint molecules by (I) competitively binding with immune checkpoint molecules to block their combination with paired ...

First author Dr. Jan Petersen said, "The way the PD-1 and CTLA-4 immune checkpoint molecules bind to their respective ligands has been resolved for many years. "However, the resolution of the ...

The difficulty in targeting immune checkpoint proteins is their flat and dynamic surfaces, which don't bind small molecules easily. To address this issue, Gabr and Abdel-Rahman looked to the co ...