A breakthrough study has uncovered a hidden player in Parkinson’s disease—24-OHC, a cholesterol metabolite that fuels the ...

Biosynthetic pathways for secondary metabolites ... The tryptophan pathway makes tryptophan, the cholesterol pathway makes cholesterol, and neither pathway makes side products.

Our objective is the elucidation of signalling pathways with an impact on cholesterol metabolism regulation. Specifically, we aim to discover novel genes and their encoded products that could ...

A new Moffitt Cancer Center study has identified a specific immune response that may prevent the spread of breast cancer ...

Researchers combined animal models, human brain tissue, and molecular analysis to uncover a connection between Alzheimer's ...

Compounds derived from the isoprenoid/cholesterol biosynthetic pathway have recently been shown to have novel biological activities. These compounds include certain sterols, oxysterols ...

Statins work by blocking a protein in the cholesterol biosynthesis pathway called HMGCR. The idea was to attack the cholesterol pathway from two angles by combining simvastatin, a widely ...

Our aim was to evaluate the changes of cholesterol metabolism induced by malabsorptive and restrictive surgery independent of weight loss. Results—Subjects had similar values at baseline.

The researchers observed that several genes associated with cholesterol metabolism were significantly downregulated when PIN1 was knocked out. Daniel Eduardo Gomez, a physician scientist at the ...