Dr. Sabatine: Clopidogrel is a prodrug and it needs to ... The IIb/IIIa inhibitor attenuates platelet aggregation by a separate mechanism. Dr. Hutter: Just replacing an ineffective one with ...

Overall, prasugrel may be superior to the approved dose of the older drug, clopidogrel (Plavix), in many cases. But more doctors have been using an initial, higher-than-standard dose of ...

Since clopidogrel is a prodrug that must be converted into an active metabolite by the cytochrome P450 2C19, patients who are carriers of CYP2C19 loss-of-function genetic variants are more prone ...

Pharmacodynamic studies have demonstrated that selected proton pump inhibitors (PPIs) decrease the pharmacodynamic effects of clopidogrel. [16] Retrospective analyses have suggested that the ...