Kidney Int 70: 963–968 Sustained low-efficiency ... replacement therapy (CRRT), high-cost modalities associated with coagulation problems, hypotension and poor fluid removal.

"Given both nutrients' critical involvement in coagulation, in extreme cases ... This can ultimately cause a build-up of vitamins in your kidney and liver, especially when take in high doses ...

With respect to risks, GLP-1RA use was significantly associated with an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, drug-induced pancreatitis, and other ...