It is well known that codon bias and gene expression ... These findings support the hypothesis that strong secondary structure at the 5′ end of an mRNA blocks ribosome binding and delays ...

Recent publications analyzing the relationship between local free energy and siRNA efficiency 4,5 have demonstrated that mRNA target site secondary structure ... from the start codon and the ...

In summary, the development and optimization of mRNA delivery systems are critical to advancing mRNA-based medicines. Through innovative nanoparticle technology and strategic therapeutic targeting, ...