Common antiplatelet medications include aspirin, which inhibits the enzyme cyclooxygenase-1 (COX-1), and clopidogrel, which blocks the P2Y12 receptor on platelets. By preventing platelets from ...

Platelets play an important role in atherothrombotic disease. The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A 2 synthesis, ADP-mediated ...

Pharmacogenomics has been implicated in the response variability of antiplatelet drugs in coronary artery disease (CAD), particularly for aspirin and clopidogrel. A large number of studies and ...