Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

One is that the DNA template somehow becomes defective during replication, and causes the polymerase to pause (Figures 3 and 4a). For example, a DNA base can be chemically modified or ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...

This repository offers a suite of Jupyter notebooks designed for the analysis of DNA polymerase dynamics at the replicaiton fork using fluorescence microscopy images and force measurement data. It ...

Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of new replication assays. These studies have accelerated DNA polymerase ...

The double helix unwinds, and each strand serves as a template for the synthesis of a new complementary strand. DNA polymerase enzymes facilitate this process, ensuring accurate copying of the genetic ...

If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...