Diltiazem was shown to slow down photoreceptor degeneration in the rd mouse, an animal model for retinitis pigmentosa 1. Rod cell numbers were quantified after cell labeling with the rho-4D2 ...

Inherited retinal diseases (IRDs) are a group of monogenic disorders caused by mutations in more than 280 genes, and are characterized by progressive degeneration of photoreceptor cells in the retina.

In view of the oxygen-rich environment in the eye, it is particularly noteworthy that phospholipids containing docosahexaenoic acid (DHA), which are exquisitely sensitive to oxidative damage (1), are ...

Two new compounds may be able to treat retinitis pigmentosa, a group of inherited eye diseases that cause blindness. The compounds, described in a study published January 14th in the open-access ...

A multidisciplinary team of researchers from the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) and ...

More information: Guizhi Guo et al, Disruption of photoreceptor cilia is a critical event in the pathogenesis of retinal degeneration—Insights from N-methyl-N-nitrosourea-induced mouse model ...

A new study reveals the potential of two compounds in treating retinitis pigmentosa, a blinding genetic disorder. These compounds, identified through virtual screening, have shown promising results in ...

This disrupts normal cell metabolism, leading to the death of photoreceptor cells and, eventually, geographic atrophy, which causes irreversible vision loss. Wet macular degeneration accounts for ...

The companies will work together by using the codon-optimized BBS1 AAV9 vector to minimize the vision loss caused by the ...

The US Food and Drug Administration (FDA) has granted regenerative medicine advanced therapy (RMAT) designation to Beacon ...