At P15, endosomes are rapidly recruited to enlarge spines. At immature and adult ages, the dendritic shaft contains SER that forms bridges where glutamate receptor trafficking is slowed in regions of ...

where it forms a diffusion barrier to prevent the movement of proteins between different membrane compartments, is replicated in neurons, where it might separate the spine and the dendritic shaft.

Synaptic plasticity relies in part on protein degradation by proteasomes, which move from the dendritic shaft to spines and are activated following synaptic excitation. Sheng and colleagues now ...