A study by Mellqvist et al. has assessed the efficacy and safety of combined bolus-dose cyclophosphamide and pulse-dose dexamethasone (Cy-Dex) as initial treatment for patients with myeloma.
In patients who have received less than 14 days of dexamethasone therapy, treatment may be abruptly discontinued without adverse events, because the HPA axis is not suppressed (Kountz & Clark ...