Lissencephaly is a devastating genetic disease of children that affects the embryonic development of the brain. It is caused by haploinsufficiency of the Lis1 gene product, which seems to be ...

Knoblich cautioned that the organoids are not “brains-in-a-jar.” “We’re talking about the very first steps of embryonic brain development, like in the first nine weeks of pregnancy,” he said. “They’re ...

In a nutshell Female cells randomly use either the maternal or paternal X chromosome—this study shows that relying more ...

An international research team led by Karolinska Institutet has mapped the early genetic development of the brain and can now present an atlas of embryonic development between weeks six and 13.

They observed a clear correlation between less OGT activity and more severe effects on embryonic development. Their results showed that OGT played an important catalytic role, and it wasn't just ...

Their work reveals the secrets of the Balbiani body (Bb), a remarkable structure that organizes essential molecules to guide early embryonic development. Using zebrafish models and cutting-edge ...

The Deneen Lab seeks to unlock the enigmatic biology surrounding glial cell development and function in the brain. Beginning with developmental gliogenesis, we identified the key transcriptional ...