an induced fit basis for substrate specificity of enzymes was rationalized from simple physical principles of enzyme kinetics. Of particular note is the proposal that ‘entropic guidance’ contributes ...

Given the tight link between binding and catalysis, this result has clear implications for promiscuity in ancestral enzymes. More importantly, it is now possible to move beyond sequence ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

A new ML-guided platform can design thousands of new enzymes, predict how they will behave in the real world, and test their performance.

Despite knowing that the active centres of many metalloprotein enzymes are iron porphyrin ... nanoporous array shows promise for biomimetic catalysis. What if synthetic iron porphyrins could ...

Areas of expertise Most biochemical reactions depend on enzyme catalysis, and understanding how enzymes 'work' at the molecular level is a fundamental problem. Enzymes are remarkably efficient and ...

Extant enzymes are prodigious catalysts, accelerating chemical reactions by as much as 25 orders of magnitude. However, it is safe to say that no enzyme is perfect in the sense of catalyzing only a ...

Taking inspiration from enzymes, chemists at the University of Illinois Urbana-Champaign developed a catalyst to simplify the ...

Enzymes are crucial to life. They are nature's little catalysts. In the gut, they help us digest food. They can enhance perfumes or get laundry cleaner with less energy. Enzymes also make potent ...