Small-molecule enzyme-inhibitors often display insufficient affinity and selectivity for their targets causing unwanted side effects when used as drugs. Molecularly imprinted polymers prepared ...

Actinogen Medical Limited (ASX: ACW) announces that the World Health Organization (WHO) has granted the nonproprietary name ...

Influencing their activity can control their rates of reaction. Different chemicals can influence enzyme activity. Inhibitors can be used to stop an enzyme from binding to its substrate.

In the brain, the enzyme ABHD6 degrades a key endocannabinoid molecule known as 2-arachidonoylglycerol (2-AG). With the discovery in 2016 that whole-body inhibition of ABHD6 reduced body weight ...

Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive.

Other NSAIDs do not have this effect. Cox-2 inhibitors are a newer form of prescription NSAID. As you might guess, they only affect Cox-2 enzymes and not Cox-1. Two of them -- Bextra and Vioxx ...

Mineralys Therapeutics (MLYS) has completed enrollment in the Explore-CKD Phase 2 trial evaluating the efficacy and safety of lorundrostat for ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...

The study's findings are crucial in the rapidly emerging field of developing disease-modifying therapies that target microglia.