to target both ERK and p38 or JNK pathways, might produce better anti-tumor effects on PAs. This article reviews the advances in understanding the role of MAPK signaling in pituitary tumorigenesis, ...

Spatiotemporal network dynamics govern cell fate decisions. We use the extracellular signal-regulated kinase (ERK) pathway as a paradigm to describe how temporal activation kinetics and spatial ...

Influenza and some other RNA viruses rely on the Raf/MEK/ERK signaling pathway inside human cells to replicate. Atriva’s lead candidate, ATR-002, is a small-molecule inhibitor of MEK ...

LL-37 levels were correlated to cell differentiation which was determined by alkaline phosphatase (AP) activity. In addition, intracellular signalling pathways such as MEK-ERK (mitogen/extracellular ...

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies. The laboratory is ...

2 The mitogen-activated protein kinase ERK pathway is the major signal transduction cascade that regulates cell growth. In myeloma the most frequently observed recurrent mutations involve this pathway ...

KRAS mutation in endothelial cells activates the MEK/ERK pathway, but has no direct effect on PI3k. Subsequently, KRAS/BRAF activates the Notch pathway or TGFb/BMP pathway through the MEK/ERK ...