What makes BA-MCY unique is that it has the opposite effect, instead of reducing bile production, BA-MCY inhibits FXR and boosts ... gut microbes and intestinal cells underscores a complex ...

which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice ...

More information: Ju-Hyun Ahn et al, Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease, Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.11.012 ...

Scarb2 deficiency is associated with alterations in gut microbiota composition and increased intestinal FXR signaling, leading to impairments in lipid absorption and the renewal of the intestinal ...