What makes BA-MCY unique is that it has the opposite effect, instead of reducing bile production, BA-MCY inhibits FXR and boosts ... gut microbes and intestinal cells underscores a complex ...

which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice ...

Scarb2 deficiency is associated with alterations in gut microbiota composition and increased intestinal FXR signaling, leading to impairments in lipid absorption and the renewal of the intestinal ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

More information: Ju-Hyun Ahn et al, Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease, Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.11.012 ...