Nature1 个月
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
Fatty acids function both as an energy source and as metabolic signalling molecules and affect many vital processes. This complexity combined with the chemical characteristics of lipids present ...
The EMBO Journal1 个月
Partitioning of fatty acids between membrane and storage lipids controls ER membrane expansion
PDAT enzymes use membrane phospholipids as direct fatty acid donors to generate triglycerides stored in lipid droplets. This study identifies an inhibitory segment within the budding yeast PDAT Lro1, ...
gut.bmj2 个月
Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate ...
Free fatty acids (FFAs) and their metabolites are important mediators of lipotoxicity ... and this upregulated MPST promotes NAFLD via inhibition of the CSE/H 2 S pathway. Liver biopsies from liver ...
A cellular model system for drug development in fatty liver disease
The liver cells come from several healthy donors. A simple treatment with low concentrations of free fatty acids over a few ...
gut.bmj4 个月
Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis
Design By mass-spectrometry, we identified and quantified free long chain fatty acids (LCFAs) in probiotics and assessed the effect of one of them in mouse colitis. Conclusion The production of ...
BMJ2 个月
Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated ...
Saturated long-chain free fatty acids (FFAs) can provide such a signal and stimulate transcription of pro ... Methods Freshly isolated peripheral blood mononuclear cells (PBMCs) from healthy donors ...