In hepatocytes, ferroptosis faces physiological constraints due to the liver's multilayered antioxidant systems. These include ferritin-mediated iron sequestration, GPx4 activity, and high levels ...

Ferroptosis is an iron-dependent non-apoptotic ... Serum samples of all patients were collected to determine ferritin levels. Molecular features responsible for pulmonary pathologies in human ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...