疗效机制不明确和新药开发困难是中医药现代化研究面临的两大瓶颈。陈士林研究团队提出全基因组泛GPCR药物发现平台的设计理念，打造以GPCR为核心的“药靶同筛”中药开发新范式，为中药研究提供了新思路。导读GPCR（G Protein-Coupled ...

▎药明康德内容团队编辑（来源：上海科技大学）近日，上海科技大学iHuman研究所徐菲课题组与华中科技大学刘剑峰团队合作，在《自然·通讯》（Nature Communications）上发表了题为“Structural insights into ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...

Talquetamab is a T-cell–redirecting bispecific antibody targeting G protein–coupled receptor class C group 5 member D (GPRC5D). 13-15 In the MonumenTAL-1 study, more than 71% of the patients ...

Predators and prey in the ocean rely on chemical signals for survival, but this vital sensory mode can also be their Achilles ...

G protein-coupled receptor kinase 2 (GRK2) is involved in heart failure (HF) progression and its upregulation contributes to adverse cardiac remodeling and dysfunction. In mouse models of HF, ...

Simcere Zaiming will receive an upfront payment from AbbVie and is eligible to receive option fees and milestone payments of ...